The Single Cell Center Heidelberg (SCC-HD) is an initiative comprised of groups from the University of Heidelberg, the Heidelberg University Hospital, the European Molecular Biology Laboratory (EMBL), and the German Cancer Research Center (DKFZ). As a hub for interdisciplinary science, Heidelberg is home to many leading groups in the single cell genomics field. The Single Cell Center nucleates groups within the four institutes to foster the growth and development of single cell genomics in the life science community. We address unmet needs in experiments and data analysis for life science projects that involve the development and application of single cell methodologies. In pursuit of this goal, the Center encourages interactions and the exchange of expertise, promotes collaborations among groups located at different sites, and enhances the visibility of groups utilizing single cell sequencing approaches at both national and international levels.